The North-Est Region is the largest development region in Romania, having two strong economic sectors, namely services and the manufacturing industry. The region creates, transfers, and implements innovation in a systemic manner using the RIS3 regional strategy, where innovators can transform local resources into products with high added value. In the last years, the suspended particle indicators have exceeded the maximum admitted values in the urban areas (PM10 and PM2.5) while economically, the region showed a low contribution to the national gross domestic product in IC&T sector.